Hematopoietic Triad Benchmark • n = 100 CRISPRi Pairs
Resolving the non-coding genome.
Complex problems require simple solutions.
TrueLocus assigns true target genes to non-coding CRISPR hits across diverse lineages. No cell-type Hi-C required.
69.0% Pooled Top-1 (n=100)81.0% Top-1 B-Cells (GM12878)100.0% Top-3 T-Cells (Jurkat)
TrueLocus
3D Chromatin ArchitectureEnhancer-Promoter Contacts
The Challenge of Non-Coding Targets
CRISPR screens find important non-coding regions, but identifying the exact gene they control is difficult. Simply picking the nearest gene often fails because DNA loops in 3D space. In our 100-pair multi-lineage benchmark, the correct target was NOT the nearest gene in 49% of cases.
Conventional Path
Months of Wasted Effort
Testing the wrong genes based on distance alone wastes months of research and resources.
TrueLocus Engine
Zero Cell-Type Hi-C Required
Uses sequence-derived architecture to identify target genes before in vivo commitment.
Inquiries & Pilot Evaluations
We work directly with target discovery teams.
To evaluate your hits or request benchmark data:
